Benefits of CBD Oil: What we know in 2020

 

a question mark drawn in chalk on a chalkboard

 

Benefits of CBD: How much is hype and how much is real?

 

Most of us are seeing claims from social media, hear-say, and blog posts on CBD oil information. There are few that actually dissect medically published studies and CBD research. There are too many false claims and brands looking to make a quick buck. Many articles will promise the world to you with the help of CBD oil. Universities, physicians, and researchers have conducted and published studies that we have laid out below.

 

 

Let’s be very clear. The research we share with you shows massive potential and clearly benefited the test subjects. Part of the problem with CBD oil research is that it has been has been forbidden or illegal, for decades, the FDA is starting to now conduct phase 3 trials with certain pharma companies. CBD oil studies will significantly increase in the next few years!

 

Omnia is not presenting this information as treatment for disease. 
We’re presenting medical research and letting you decide for yourself.
Any article you read about science or claims needs to have references from credible sources. We want to make sure we present the best CBD research that has ever been conducted.

 

 

What do we know about CBD?

 

CBD is a cannabinoid from the cannabis plant. Once inside your body, it raises levels of two neurotransmitters called anandamide (aka the bliss hormone) and 2-AG. These cause a cascade of effects all over your body.

Raising the levels of anandamide and 2-AG along with the after-effects is the bottom line.

This is where the “magic” happens. All the research done by doctors and scientists through universities all over the world is looking at what happens and why it happens once CBD causes these changes.

CBD likes fat and hates water. We know that the highest rates of absorption are inhaled (not very safe) and under the tongue, or sublingual, which is the most common. We’ve created a guide for taking CBD properly here

 

CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition basic and clinical investigations on the effects of CBD, have been carried out in the context of many other health conditions. Including its potential use ; Epilepsy, substance abuse, dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson(s).

 

– Dept. of Neurosciences and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paolo

 

What has the research on CBD looked at?

 

To name a few:

  • Inflammation
  • Anxiety
  • Depression
  • Sleep
  • Cancer
  • Pain
  • Parkinson’s
  • Seizures
  • Multiple Sclerosis
  • Fibromyalgia
  • Diabetes
  • PTSD
 

 

Inflammation

 

How does CBD affect the inflammatory response?

According to this study by the University of Mississippi, the human body creates something called oxidative stress which is a complex defense mechanism that is part of the immune system. Occasionally, the body overdoes it with this oxidative stress and it can damage tissues and even organs.

The study continues to show that CBD can blunt the effects of oxidative stress by stimulating the endocannabinoid system.

“This review discusses recent studies suggesting that cannabidiol may have utility in treating a number of human diseases and disorders now known to involve activation of the immune system and associated oxidative stress, as a contributor to their etiology and progression. These include rheumatoid arthritis, types I and II diabetes, atherosclerosis, Alzheimer’s disease, hypertension, the metabolic syndrome, ischemia-reperfusion injury, depression, and neuropathic pain. ” In most in vivo models of inflammation, CBD attenuates inflammatory cell migration/infiltration”

- Department of Pharmacology and Toxicology, School of Medicine, and the Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center

 

 

Anxiety

 

The effects on anxiety is one of the most common topics of CBD research and surely one of the most marketed uses for the sale of CBD products.

This study published by the British Journal of Pharmacology shows how CBD can blunt effects of anxiety in rats exposed to stress. The basis of the conclusion of this study found that CBD stimulates specific receptors that reduce anxiery. (Specifically 5‐HT1A if you’re interested!)

They tested CBD on rats that were placed in a maze to elevate their heart rates. The rats were given CBD 30 minutes before being placed in the maze. Exposure to RS (restraint) increased blood pressure, heart rate, and induced an anxiogenic response in the EPM (elevated pulse maze) 24h later. These effects were attenuated by CBD.

the present findings indicate that CBD, by activating 5‐HT1A receptors, can attenuate physiological and behavioural responses to restraint stress. This finding raises the possibility that CBD could be useful for treating psychiatric disorders thought to involve impairment of stress‐coping mechanisms, such as depression and post‐traumatic stress disorder.

Authors Leonardo B.M. Resstel, Rodrigo F. Tavares, Sabrina F.S. Lisboa, Sâmia R.L. Joca, Fernando M.A., Corrêa, Francisco S., and Guimarães of '5‐HT1A receptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats'

 

 

Depression

 

There are so many people that suffer from depression. The sad reality is most of us do not seek treatment or report it to anyone. Depression as a disease can be the result of many factors. In this study out of the University of Sao Paulo they brought up the following points:

It has recently been suggested that the endocannabinoid system may be involved in the pathophysiology of depression (Hill and Gorzalka, 2005). This is supported by several pieces of evidence showing that endocannabinoids and CB1 receptors are widely distributed in brain areas that are often related to affective disorders (Devane, 1988) and that their expression is regulated by antidepressant drugs

In these CBD oil studies, the targeted areas of the brain that affect depression in mice as they do in humans. They compared the results of CBD to those of imipramine, a very potent antidepressant. They concluded:

The fact that depression (at least some forms) can be reversed with a heavy-duty medication the same as this all-natural plant, according to this study, is something that requires a significant amount of research and understanding put towards it.

CBD induces antidepressant-like effects comparable to those of imipramine. These effects of CBD were probably mediated by activation of 5-HT1A receptors.

Department of Pharmacology and Toxicology, School of Medicine, and the Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center

CBD induces antidepressant-like effects comparable to those of imipramine

Dept of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo

 

 

Sleep

 

In mild doses, CBD may increase wakefullness. This study out of Mexico’s Universidad Autonoma de Campeche, found that “CBD enhanced wakefulness and decreased slow wave sleep and REM sleep”

This dose of CBD in test was given in micrograms instead of milligrams. So, a smaller dose showed increase in wakefullness in brain activity.

It may have applications in sleep disorders related to other medical conditions as well.

Take Parkinson’s for example. A rampant problem in patients with Parkinson’s is a disruption in REM sleep. This is the deep sleep that plays a vital part in the healing and anti-inflammatory processes of your body.

This study from Brazil showed that the patients studied “…had prompt and substantial reduction in the frequency of RBD-related events without side effects.”

 

University of Colorado School of Medicine in Fort Collins published this case report. A 10 year-old girl was sexually assaulted and suffered from PTSD. The report describes that she was losing sleep due to PTSD and medication would not help. Her sleep cycle improved when they gave her CBD oil. Continue reading to see more research in regards to PTSD and CBD.

 

 

Cancer

 

This topic could have its own book. We’ll try to keep it informative without being too lengthy. We can’t understand the benefits of CBD with cancer just yet. Most studies have not been performed in humans and tumor studies are tricky. They don’t translate from lab dishes, to animals, and then to humans with a guarantee that they’ll all react the same.

So, really we don’t have a definitive answer on how CBD will affect cancer in humans until we do more human trials. But, the preliminary CBD research is promising.

 

 

The American Cancer Society has CBD on their radar as a potential future treatment option, they even have marijuana and THC as a current treatment option on their website

Forbeswrote a reaction to a study where survival from cancer in mice tripled when CBD was taken with chemo. It goes without saying that the cancer treatment and pharmaceutical industry are interested (for good and bad reasons) in the effects of CBD as well as THC.

There is a plethora of published research at your fingertips, with a simple google search you can check out several of these studies.

More recently, scientists reported that THC and other cannabinoids such as CBD slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer.

- The American Cancer Society

 

CBD has been tested on the following cancers:

Bladder
Brain
Breast
Colon
Endocrine
Leukemia
Lung
Prostate
Skin Cancer

a syringe placing liquid in small test tubes to analyze the benefits of CBD oil

 

So, what does CBD oil do to cancer? According to this study out of the Complutense Unversity in Madrid, Spain, we’ve known since 1975 that cannabinoids stop the growth of, and sometimes even kill tumor tissue on mice with tumors. However, this study was performed with THC and synthetic cannabinoids.

Typically, researchers shy away from THC in general because of its psychoactive properties.
This is an extensive study that cites other research done by scientists and experts in their respective fields, dating back for decades.

Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread

 - The Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy

 

 

Pain

 

Another widely researched area of CBD’s application is pain relief. It is quite possible that CBD does not have a direct effect on pain as much as another compound in the hemp plant, an ingredient in CBD oil, called Myrcene. It is a terpene that is absolutely fascinating.

Beta myrcene was found in 1990 to work on the same parts of your brain and spinal cord that opiates work on. Again, with no “high” or psychoactive effects like heroin or oxycodone. The effects of this terpene are even blocked by Narcan, which is what’s used to reverse an overdose on opiates like heroin. This above study, published by the Royal Pharmaceutical Society of Great Britain found that unlike Morphine, the rats tested with myrcene did not become addicted like they did with morphine. Almost too good to be true.

Again, this compound is a concentrated ingredient in CBD oil. Most people just assumed that the pain relieving effects of a cannabis plant were from THC, the compound in marijuana that makes you feel high. There is significant evidence from piles of research that suggest otherwise.

The endocannabinoid system is tonically active in control of pain…
“…Cannabinoids proved to be 10-fold more potent than morphine in wide dynamic range neurons mediating pain

- Schrier Research Laboratory, Department of Psychology, Brown University

 

 

Parkinson’s

 

Parkinson’s is a disease that has been studied for decades and on fundamental level, the medical field understands what is happening to the human body with the disease.

The underlying issue is this: the nervous system is not producing the hormone Dopamine adequately.

The significant breakthrough in the CBD-Parkison’s research happened when the University of Louisville School of Medicine found that CBD can target a protein that will stimulate dopamine production.

This protein, called GPR6 (G Protein Coupled Receptor #6) has been called an “orphan receptor” because researchers have been unable to find anything in the body that can bind to it.

These results demonstrate for the first time that both GPR3 and GPR6 are novel molecular targets for CBD. Our discovery that CBD acts as a novel inverse agonist on both GPR3 and GPR6 indicates that some of the potential therapeutic effects of CBD (e.g. treatment of Alzheimer’s disease and Parkinson’s disease) may be mediated through these important receptors.

 

- Department of Pharmacology and Toxicology, University of Louisville School of Medicine

Our findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities”
“No adverse effect was observed during the treatment. These preliminary data suggest that CBD may be effective, safe and well tolerated for the treatment of the psychosis in PD.

- Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo

In summary, our results indicate that those cannabinoids having antioxidant cannabinoid receptor-independent properties provide neuroprotection against the progressive degeneration of nigrostriatal dopaminergic neurons occurring in PD (Parkinson’s Disease).

- Departamento de Bioquímica y Biología Molecular III, Facultad de Medicina, Universidad Complutense, Madrid

 

 

Seizures

 

Let’s start with this: the FDA just approved (November 2018) the drug Epidiolex for 2 types of epilepsy after rigorous double-blind trials. The main ingredient in Epidiolex? CBD.

The results of these FDA trials on Epidiolex were as follows: Patients saw their seizures reduced by an average of about 50%. And, 5% of patients actually had their seizures eliminated completely.

The exact actions of CBD on seizures is not quite known according to the University of Pavia in Italy.

What we do know is that there have been several studies and the results are pretty clear across the board. A study from Korea published results from their research.

… the molecular actions involved in CBD anti-seizure activity do not appear to be mediated by a direct effect on cannabinoid receptors, but the precise mechanisms of action have not been ascertained

- Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Italy

Several such studies have shown that CBD does have efficacy for treatment of epilepsy.”
“ As such, we might expect CBD to show efficacy and safety in the treatment of epilepsy.”
“They observed a decrease of 36.5% and 16% in tonic seizures and tonic-clonic seizures, respectively. Overall, the median monthly frequency of motor seizures decreased by 47%.

- Department of Pediatrics, Changwon Gyeongsang National University Hospital, Changwon, Korea.

 

 

Multiple Sclerosis

 

As with seizures, there is a drug with CBD used to treat MS called Sativex. This drug is not sold in the USA because it has a 1:1 ratio of CBD to THC.
We wanted to know what CBD could do without THC for the treatment of MS.

There are 2 major problems in the body with MS: the main problem is the “skinning” of nerves (called de-myelination) where the electrical conduction is ruined. Secondly, is inflammation.

While it really isn’t understood how exactly CBD helps inflammation in MS, it is understood how CBD targets the development and/or progression of MS.

Together, our findings highlight the anti-inflammatory effects of CBD in this viral model of MS and demonstrate the significant therapeutic potential of this compound for the — of pathologies with an inflammatory component.

- Department of Functional and Systems Neurobiology, Neuroimmunology Group, Cajal Institute, CSIC, Madrid, Spain

This study was aimed to investigate whether treatment with purified cannabidiol (CBD) may counteract the development of experimental multiple sclerosis (MS), by targeting the PI3K/Akt/mTOR pathway.
Finally, CBD was found to promote neuronal survival by inhibiting JNK and p38 MAP kinases

- IRCCS Centro Neurolesi "Bonino-Pulejo" (Ministry of Health, Italy)

 

 

Fibromyalgia

 

Like we stated at the beginning of this article, there is no guarantee that any of this research will turn out to be FDA (or another gov’t agency) approved for medicine. Some applications have less evidence for being beneficial, like fibromyalgia. Dr. Ethan Russo, who we believe to be one of the few true experts in this field, produced the following study regarding fibromyalgia and CBD.

On the other hand, the National Institutes of Health (NIH) in the USA found no evidence of CBD working for fibromyalgia in this study.

Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines”

- Ethan Russo, MD Director of Research and Development at International Cannabis and Cannabinoids Institute

We found no convincing, unbiased, high quality evidence suggesting that nabilone is of value in treating people with fibromyalgia. The tolerability of nabilone was low in people with fibromyalgia.

- National Institutes of Health (NIH) in the USA

 

There isn’t too much research out there yet. However it’s quite possible an application could be found for fibromyalgia. Right now it is unclear if it has the same potential as the other applications in this post.

 

 

Diabetes

 

The science behind how and why CBD is a potential treatment to reduce the incidences diabetes in mice without obesity is very complex. If you’d like to see the science behind it, click here to see a study out of Jerusalem.

Another serious complication with diabetes is blindness. CBD has been studied to treat this inflammation of the retinas associated with diabetes by the College of Georgia. It goes back to reducing that oxidative stress that was mentioned earlier in the article.

We now report that CBD treatment significantly reduces the incidence of diabetes in NOD(non-obese diabetic) mice from an incidence of 86% in non-treated control mice to an incidence of 30% in CBD-treated mice…resulting in a decreased incidence of diabetes

- Hadassah University Hospital, Department of Bone Marrow Transplantation & Cancer Immunotherapy, Jerusalem, Israel.

The function of CBD as an antioxidant to block oxidative stress and as an inhibitor of adenosine reuptake to enhance a self-defense mechanism against retinal inflammation represents a novel therapeutic approach to the treatment of ophthalmic complications associated with diabetes.

- Gregory I Liou, Department of Ophthalmology, Medical College of Georgia

 

 

PTSD

 

This study  that was a collaboration by a few universities in Colorado including University of Colorado Denver and Colorado State University found that the severity of PTSD symptoms in adults was reduced by the administration of CBD daily for 8 weeks.

Administration of oral CBD in addition to routine psychiatric care was associated with PTSD symptom reduction in adults with PTSD. CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD. Additional clinical investigation, including double-blind, placebo-controlled trials, would be necessary to further substantiate the response to CBD that was observed in this study.

- Conclusion from 'Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.' a collaborative study by, Elms L, Shannon S, Hughes S, Lewis N.

 

 

Benefits of CBD FAQs

The World Health Organization (WHO) stated CBD does not show any potential for abuse or addiction. It does not stimulate the parts of the brain that cause addiction and produces no feeling of intoxication

While there is a lethal dose of CBD, just like there is a lethal dose for everything, including water, CBD does not cause one to go unconscious and stop breathing like an opiate. The lethal dose of CBD was found to be 615mg/kg which is an astronomical amount

The World Health Organization stated that CBD has a very high safety profile. CBD that is suspended in hemp seed oil is rich in omega fatty acids. As long as you’re taking a quality CBD, yes it is safe for use every day

CBD is a known anti-convulsant, anti-anxiety, pain reliever and sleep aide. It is being researched for many different applications including Autism, Parkinson’s, Cancer, and Autoimmune diseases.

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Conclusion

 

Research shows CBD to have an immense potential for treating a huge list of disorders and ailments. Most importantly it needs to be researched more. Side effects of CBD are extremely low and infrequent. The side effects that have been documented are minor ones, like nausea for example. Most other side effects are due to mixing with prescription medication. However one thing is for sure – CBD is safe and healthy for the human body. The only danger a consumer will encounter is a low-quality product.

 

About the Author:

a short bio of Jon Vought

 

 

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